Overview

The Center for Cardiometabolic Risk Reduction in South Asia Study (CARRS) is a state-of-the-art, population-based cohort of South Asians to address existing and emerging questions related to cardio-metabolic disease.

Heart disease and diabetes are the leading cause of morbidity and mortality worldwide. India and the South Asian region broadly are at the epicenter of the cardiometabolic diseases epidemic.

The CARRS Cohort follows a diverse population-based sample of more than 20,000 South Asian adults age ≥ 20 years, with ongoing follow-up for clinical cardiovascular risk factors, clinical disease, and mortality. The cohort was recruited in two waves, CARRS-1 in 2010-11 and CARRS-2 in 2015-16, and has high retention rates (70-85% annual follow-up, 88% hybrid tele/in-person attendance even during COVID, and >95% have at least one follow-up or death in 10 years of follow up) with a biorepository of 360,000 stored samples.

Quick Facts

Cohort

> 20,000 South Asian adults

> 20 years

Recruitment

CARRS 1 (2010-11)

CARRS 2 (2015-16)

Study Sites

Chennai, India

Delhi, India

Stored Samples

360,000 samples

Research Areas

Precision-CARRS

Aims to transform the current cardiovascular disease risk prediction model to a more personalized, precise approach that enables early detection.

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CARRS Brain

Aims to characterize midlife cognitive impairment and identify risk factors for Alzheimer's disease and related dementias in participants aged 40 and above.

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