CARRS Brain

Dementia is the defining

public-health challenge

of our aging world.        

7.4%

of adults aged 60+—nearly 8.8 million people—are living with dementia

150M+

By 2050, more than 150 million people globally will be living with dementia.

Urgent

Critical need for population specific data

To address this gap, CARRS is capturing risk profiles and applying phenotyping strategies that are rigorous, scalable, and internationally comparable.

India cannot afford inaction

Baseline prevalence of modifiable dementia risk factors 

South Asia is poised to account for a substantial share of the future global dementia burden. 

Purpose of the Study

Understand Life-Course Origins

To understand how Alzheimer’s disease and related dementias develop across the life course in South Asian populations—long before clinical symptoms emerge.

Integrate Multimodal Risk

To integrate genetic, cardiometabolic, socio-behavioral, environmental, and brain phenotyping data to map heterogeneous pathways to cognitive impairment.

Predict and Prevent

To identify high-risk profiles and develop prediction frameworks to inform dementia prevention strategies tailored to South Asia.

Study Framework

CARRS-Brain extends the parent cohort using a three-tiered phenotyping framework that balances scalability with in-depth characterization:

Tier (1) – Genomics and plasma biomarkers

Stored baseline biospecimens are used for whole-genome sequencing and Alzheimer’s disease and related dementias (AD/ADRD) plasma biomarker assays.

Tier (2) – Follow-up cognitive and biomarker assessment

At a dedicated follow-up visit outside routine CARRS examinations, participants complete digital cognitive phenotyping and repeat blood collection.

Tier (3) – Multimodal deep phenotyping (age ≥50 years)

A subset of participants undergo comprehensive evaluation, including

  • Population-validated neuropsychological testing

  • Brain MRI

  • Retinal imaging

  • Wearable-based assessment of physical activity, stress, and sleep

Pillars of Data Collection

Neurocognitive Assessment

Brain Imaging

Retinal Imaging

Wearables

Lab Measurements

Study Measures and Documents